› 7zlr

X-ray diffraction
2.01Å resolution

Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13

Released:
DOI: 10.2210/pdb7zlr/pdb
Model geometry
Fit model/data
PDB entry 7zlr coloured by chain, front view.
PDB entry 7zlr coloured by chain, side view.
PDB entry 7zlr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Ramachandran S, Makukhin N, Haubrich K, Nagala M, Forrester B, Lynch DM, Casement R, Testa A, Bruno E, Gitto R, Ciulli A
OpenAccess logo Nat Commun 14 6345 (2023)
PMID: 37816714

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-126990 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Suppressor of cytokine signaling 2 Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14508 (Residues: 32-198; Coverage: 84%)
Gene names: CIS2, SOCS2, SSI2, STATI2
Sequence domains:
Elongin-B Chain: B
Molecule details ›
Chain: B
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15370 (Residues: 1-118; Coverage: 100%)
Gene names: ELOB, TCEB2
Sequence domains: Ubiquitin family
Elongin-C Chain: C

Ligands and Environments

1 bound ligand:
Ligand JH9 1 x JH9
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 56.112Å b: 52.246Å c: 77.458Å
α: 90° β: 108.269° γ: 90°
R-values:
R R work R free
0.203 0.2 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

The druggability of SH2 domains unmasked.
Hantschel O. (2024)