7zmc Citations

The structure of a polyketide synthase bimodule core.

OpenAccess logo Sci Adv 8 eabo6918 (2022)
Related entries: 7zm9, 7zma, 7zmd, 7zmf, 7zsk

Cited: 3 times
EuropePMC logo PMID: 36129979

Abstract

Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functional modules. Each module performs one round of precursor extension and optional modification, followed by directed transfer of the intermediate to the next module. While enzymatic domains and even modules of PKSs are well understood, the higher-order modular architecture of PKS assembly lines remains elusive. Here, we visualize a PKS bimodule core using cryo-electron microscopy and resolve a two-dimensional meshwork of the bimodule core formed by homotypic interactions between modules. The sheet-like organization provides the framework for efficient substrate transfer and for sequestration of trans-acting enzymes required for polyketide production.

Articles - 7zmc mentioned but not cited (1)

  1. The structure of a polyketide synthase bimodule core. Tittes YU, Herbst DA, Martin SFX, Munoz-Hernandez H, Jakob RP, Maier T. Sci Adv 8 eabo6918 (2022)


Reviews citing this publication (1)

  1. Application of artificial scaffold systems in microbial metabolic engineering. Liu N, Dong W, Yang H, Li JH, Chiu TY. Front Bioeng Biotechnol 11 1328141 (2023)

Articles citing this publication (1)

  1. Structure of a modular polyketide synthase reducing region. McCullough TM, Dhar A, Akey DL, Konwerski JR, Sherman DH, Smith JL. Structure 31 1109-1120.e3 (2023)