Function and Biology Details
Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
RISC-loading complex, TARBP2 variant and RNA (preferred)
PDBe Complex ID:
PDB-CPX-161306 (preferred)
Entry contents:
2 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (3 distinct):
Endoribonuclease Dicer
Molecule details ›
Chain: A
Length: 2004 amino acids
Theoretical weight: 226.93 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 2004 amino acids
Theoretical weight: 226.93 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q8R418 (Residues: 1-1916; Coverage: 100%)
Sequence domains:
RISC-loading complex subunit TARBP2
Molecule details ›
Chain: D
Length: 373 amino acids
Theoretical weight: 39.99 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Double-stranded RNA binding motif
Length: 373 amino acids
Theoretical weight: 39.99 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P97473 (Residues: 1-365; Coverage: 100%)
Sequence domains: Double-stranded RNA binding motif
