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CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: protein stabilization
Cellular component: cytosol

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EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00183
Domain description: Hsp90 protein
Occurring in:
  1. Heat shock protein HSP 90-beta
The deposited structure of PDB entry 7zr5 contains 2 copies of Pfam domain PF00183 (Hsp90 protein) in Heat shock protein HSP 90-beta. Showing 1 copy in chain A.

PF13589
Domain description: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Occurring in:
  1. Heat shock protein HSP 90-beta
The deposited structure of PDB entry 7zr5 contains 2 copies of Pfam domain PF13589 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in Heat shock protein HSP 90-beta. Showing 1 copy in chain A.

PF00149
Domain description: Calcineurin-like phosphoesterase
Occurring in:
  1. Serine/threonine-protein phosphatase 5
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF00149 (Calcineurin-like phosphoesterase) in Serine/threonine-protein phosphatase 5. Showing 1 copy in chain E [auth P].

PF08321
Domain description: PPP5 TPR repeat region
Occurring in:
  1. Serine/threonine-protein phosphatase 5
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF08321 (PPP5 TPR repeat region) in Serine/threonine-protein phosphatase 5. Showing 1 copy in chain E [auth P].

PF00515
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 5
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF00515 (Tetratricopeptide repeat) in Serine/threonine-protein phosphatase 5. Showing 1 copy in chain E [auth P].

PF07714
Domain description: Protein tyrosine and serine/threonine kinase
Occurring in:
  1. Serine/threonine-protein kinase B-raf
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF07714 (Protein tyrosine and serine/threonine kinase) in Serine/threonine-protein kinase B-raf. Showing 1 copy in chain D [auth K].

PF00130
Domain description: Phorbol esters/diacylglycerol binding domain (C1 domain)
Occurring in:
  1. Serine/threonine-protein kinase B-raf
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) in Serine/threonine-protein kinase B-raf. Showing 1 copy in chain D [auth K] (this domain is out of the observed residue ranges!).

PF02196
Domain description: Raf-like Ras-binding domain
Occurring in:
  1. Serine/threonine-protein kinase B-raf
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF02196 (Raf-like Ras-binding domain) in Serine/threonine-protein kinase B-raf. Showing 1 copy in chain D [auth K] (this domain is out of the observed residue ranges!).

PF08564
Domain description: Cdc37 C terminal domain
Occurring in:
  1. Hsp90 co-chaperone Cdc37
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF08564 (Cdc37 C terminal domain) in Hsp90 co-chaperone Cdc37. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

PF08565
Domain description: Cdc37 Hsp90 binding domain
Occurring in:
  1. Hsp90 co-chaperone Cdc37
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF08565 (Cdc37 Hsp90 binding domain) in Hsp90 co-chaperone Cdc37. Showing 1 copy in chain C.

PF03234
Domain description: Cdc37 N terminal kinase binding
Occurring in:
  1. Hsp90 co-chaperone Cdc37
The deposited structure of PDB entry 7zr5 contains 1 copy of Pfam domain PF03234 (Cdc37 N terminal kinase binding) in Hsp90 co-chaperone Cdc37. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR020575
Domain description: Heat shock protein Hsp90, N-terminal
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR006186
Domain description: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR001404
Domain description: Heat shock protein Hsp90 family
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR020454
Domain description: Diacylglycerol/phorbol-ester binding
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR037196
Domain description: HSP90, C-terminal domain
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR003594
Domain description: Histidine kinase/HSP90-like ATPase domain
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR036890
Domain description: Histidine kinase/HSP90-like ATPase superfamily
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR029052
Domain description: Metallo-dependent phosphatase-like
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR002219
Domain description: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR003116
Domain description: Raf-like Ras-binding
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR013873
Domain description: Cdc37, C-terminal
Occurring in:
  1. Hsp90 co-chaperone Cdc37
IPR013874
Domain description: Cdc37, Hsp90 binding
Occurring in:
  1. Hsp90 co-chaperone Cdc37
IPR013855
Domain description: Cdc37, N-terminal domain
Occurring in:
  1. Hsp90 co-chaperone Cdc37
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR019805
Domain description: Heat shock protein Hsp90, conserved site
Occurring in:
  1. Heat shock protein HSP 90-beta
IPR004843
Domain description: Calcineurin-like phosphoesterase domain, ApaH type
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR041753
Domain description: PP5, C-terminal metallophosphatase domain
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR013235
Domain description: PPP domain
Occurring in:
  1. Serine/threonine-protein phosphatase 5
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR001245
Domain description: Serine-threonine/tyrosine-protein kinase, catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR046349
Domain description: C1-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase B-raf
IPR038189
Domain description: Cdc37, Hsp90-binding domain superfamily
Occurring in:
  1. Hsp90 co-chaperone Cdc37
IPR004918
Domain description: Cdc37
Occurring in:
  1. Hsp90 co-chaperone Cdc37

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