› 7zt2

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-274052 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Major histocompatibility complex class I-related gene protein Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 33.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q95460 (Residues: 23-292; Coverage: 85%)
  • Best match: Q95460-5 (Residues: 23-202)
Gene name: MR1
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
E8 TCR Alpha Chain: D
Molecule details ›
Chain: D
Length: 205 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
E8 TCR beta Chain: E
Molecule details ›
Chain: E
Length: 262 amino acids
Theoretical weight: 29.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand 2LJ 1 x 2LJ
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 91.19Å b: 103.85Å c: 117.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.215 0.276
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Regulation of MAIT cells through host-derived antigens.
Ito et al. (2024)
4 other articles

1 mention without citation

Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.
Chancellor et al. (2023)