› 7zt4

X-ray diffraction
2.02Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-225760 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Major histocompatibility complex class I-related gene protein Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 33.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q95460 (Residues: 23-292; Coverage: 85%)
  • Best match: Q95460-5 (Residues: 23-202)
Gene name: MR1
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
TCR alpha Chain: D
Molecule details ›
Chain: D
Length: 205 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
TCR beta Chain: E
Molecule details ›
Chain: E
Length: 262 amino acids
Theoretical weight: 29.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand JSO 1 x JSO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 91.71Å b: 104.39Å c: 117.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.268
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Self-reactive MAIT cells are common in healthy individuals.
Flemming A. (2023)