› 7zu1

X-ray diffraction
1.68Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 29.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 672-920; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

6 bound ligands:
Ligand DHT 1 x DHT
Ligand GOL 1 x GOL
Ligand SO4 1 x SO4
Ligand DTT 1 x DTT
Ligand IMD 1 x IMD
Ligand LI 1 x LI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 55.619Å b: 66.169Å c: 70.951Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.254
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription.
Gorodetska et al. (2024)

1 mention without citation

A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.
Alegre-Martí et al. (2023)