› 7zv9

X-ray diffraction
4.51Å resolution

Crystal structure of FLT3 in complex with a monomeric FLT3 Ligand variant

Released:
DOI: 10.2210/pdb7zv9/pdb
PDB entry 7zv9 coloured by chain, front view.
PDB entry 7zv9 coloured by chain, side view.
PDB entry 7zv9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pannecoucke E, Savvides SN

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273654 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Fms-related tyrosine kinase 3 ligand Chains: A, C, E, G, I, K, M, O
Molecule details ›
Chains: A, C, E, G, I, K, M, O
Length: 155 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49771 (Residues: 27-160; Coverage: 64%)
  • Best match: P49771-3 (Residues: 1-78)
Gene name: FLT3LG
Sequence domains: flt3 ligand
Receptor-type tyrosine-protein kinase FLT3 Chains: B, D, F, H, J, L, N, P
Molecule details ›
Chains: B, D, F, H, J, L, N, P
Length: 582 amino acids
Theoretical weight: 65.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P36888 (Residues: 1-541; Coverage: 53%)
Gene names: CD135, FLK2, FLT3, STK1
Sequence domains: Immunoglobulin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P1
Unit cell:
a: 139.208Å b: 139.215Å c: 143.689Å
α: 90.02° β: 90.03° γ: 89.99°
R-values:
R R work R free
0.278 0.278 0.291
Expression systems:
  • Escherichia coli BL21(DE3)
  • Homo sapiens

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