› 7zvj

X-ray diffraction
2.61Å resolution

Homodimeric structure of LARGE1

Released:
DOI: 10.2210/pdb7zvj/pdb
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PDB entry 7zvj coloured by chain, front view.
PDB entry 7zvj coloured by chain, side view.
PDB entry 7zvj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for matriglycan synthesis by the LARGE1 dual glycosyltransferase.
Katz M, Diskin R
OpenAccess logo PLoS One 17 e0278713 (2022)
PMID: 36512577

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131937 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Xylosyl- and glucuronyltransferase LARGE1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 619 amino acids
Theoretical weight: 72.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95461 (Residues: 134-752; Coverage: 82%)
Gene names: KIAA0609, LARGE, LARGE1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand PO4 3 x PO4
Ligand MN 2 x MN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: C2
Unit cell:
a: 196.531Å b: 107.377Å c: 100.334Å
α: 90° β: 120.26° γ: 90°
R-values:
R R work R free
0.216 0.215 0.27
Expression system: Homo sapiens

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Citations

1 review citation

In silico simulation of glycosylation and related pathways.
Akune-Taylor et al. (2024)
2 other articles

2 mentions without citation

The underlying mechanisms of arenaviral entry through matriglycan.
Katz et al. (2024)
1 more

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