› 7zxb

X-ray diffraction
3Å resolution

Crystal structure of human STING in complex with 3',3'-c-(2'dAMP-2'F,2'dAMP)

Released:
DOI: 10.2210/pdb7zxb/pdb
PDB entry 7zxb coloured by chain, front view.
PDB entry 7zxb coloured by chain, side view.
PDB entry 7zxb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Klima M, Smola M, Boura E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand KAX 1 x KAX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P41212
Unit cell:
a: 111.803Å b: 111.803Å c: 35.115Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.27
Expression system: Escherichia coli BL21(DE3)

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