› 7zxn

Electron Microscopy
3.06Å resolution

cryo-EM structure of Connexin 32 gap junction channel

Released:
DOI: 10.2210/pdb7zxn/pdb
PDB entry 7zxn coloured by chain, front view.
PDB entry 7zxn coloured by chain, side view.
PDB entry 7zxn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels.
Qi C, Lavriha P, Bayraktar E, Vaithia A, Schuster D, Pannella M, Sala V, Picotti P, Bortolozzi M, Korkhov VM
OpenAccess logo Sci Adv 9 eadh4890 (2023)
PMID: 37647412
Related structures: EMD-15011

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-1 protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 283 amino acids
Theoretical weight: 32.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08034 (Residues: 1-283; Coverage: 100%)
Gene names: CX32, GJB1
Sequence domains: Connexin

Ligands and Environments

1 bound ligand:
Ligand CLR 6 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.06Å
Relevant EMDB volumes: EMD-15011
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Cx31.1 can selectively intermix with co-expressed connexins to facilitate its assembly into gap junctions.
Leighton et al. (2024)