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CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: double-strand break repair via nonhomologous end joining
Cellular component: nonhomologous end joining complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03730
Domain description: Ku70/Ku80 C-terminal arm
Occurring in:
  1. X-ray repair cross-complementing protein 6
  2. X-ray repair cross-complementing protein 5
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF03730 (Ku70/Ku80 C-terminal arm) in X-ray repair cross-complementing protein 6. Showing 1 copy in chain A.
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF03730 (Ku70/Ku80 C-terminal arm) in X-ray repair cross-complementing protein 5. Showing 1 copy in chain B.

PF02735
Domain description: Ku70/Ku80 beta-barrel domain
Occurring in:
  1. X-ray repair cross-complementing protein 6
  2. X-ray repair cross-complementing protein 5
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF02735 (Ku70/Ku80 beta-barrel domain) in X-ray repair cross-complementing protein 6. Showing 1 copy in chain A.
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF02735 (Ku70/Ku80 beta-barrel domain) in X-ray repair cross-complementing protein 5. Showing 1 copy in chain B.

PF03731
Domain description: Ku70/Ku80 N-terminal alpha/beta domain
Occurring in:
  1. X-ray repair cross-complementing protein 6
  2. X-ray repair cross-complementing protein 5
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF03731 (Ku70/Ku80 N-terminal alpha/beta domain) in X-ray repair cross-complementing protein 6. Showing 1 copy in chain A.
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF03731 (Ku70/Ku80 N-terminal alpha/beta domain) in X-ray repair cross-complementing protein 5. Showing 1 copy in chain B.

PF21928
Domain description: XLF protein coiled-coil region
Occurring in:
  1. Non-homologous end-joining factor 1
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF21928 (XLF protein coiled-coil region) in Non-homologous end-joining factor 1. Showing 1 copy in chain D [auth F] (this domain is out of the observed residue ranges!).

PF09302
Domain description: XLF N-terminal domain
Occurring in:
  1. Non-homologous end-joining factor 1
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF09302 (XLF N-terminal domain) in Non-homologous end-joining factor 1. Showing 1 copy in chain D [auth F] (this domain is out of the observed residue ranges!).

PF15384
Domain description: PAXX, PAralog of XRCC4 and XLF, also called C9orf142
Occurring in:
  1. Protein PAXX
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF15384 (PAXX, PAralog of XRCC4 and XLF, also called C9orf142) in Protein PAXX. Showing 1 copy in chain C.

PF08785
Domain description: Ku C terminal domain like
Occurring in:
  1. X-ray repair cross-complementing protein 5
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF08785 (Ku C terminal domain like) in X-ray repair cross-complementing protein 5. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF02037
Domain description: SAP domain
Occurring in:
  1. X-ray repair cross-complementing protein 6
The deposited structure of PDB entry 7zyg contains 1 copy of Pfam domain PF02037 (SAP domain) in X-ray repair cross-complementing protein 6. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

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