› 8b43

X-ray diffraction
2.49Å resolution

Crystal structure of ferrioxamine transporter

Released:
DOI: 10.2210/pdb8b43/pdb
PDB entry 8b43 coloured by chain, front view.
PDB entry 8b43 coloured by chain, side view.
PDB entry 8b43 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Primary publication:
Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.
Chan DCK, Josts I, Koteva K, Wright GD, Tidow H, Burrows LL
OpenAccess logo Proc Natl Acad Sci U S A 120 e2221253120 (2023)
PMID: 37043535

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secretin/TonB short N-terminal domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 820 amino acids
Theoretical weight: 90.06 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0C7CQY7 (Residues: 1-820; Coverage: 100%)
Gene names: CAZ10_13360, CCBH4851_00003, PAERUG_P19_London_7_VIM_2_05_10_06837, fhuA, fhuA_4
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand SO4 4 x SO4
Ligand BOG 3 x BOG
Ligand FE 2 x FE
Ligand OX8 3 x OX8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P3221
Unit cell:
a: 95.411Å b: 95.411Å c: 177.984Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.259
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Opportunities and challenges of microbial siderophores in the medical field.
Passari et al. (2023)
1 other article

1 mention without citation

Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.
Chan et al. (2023)