› 8b87

X-ray diffraction
2Å resolution

Crystal structure of Scribble PDZ1 with human papillomavirus strain 16 E6 peptide

Released:
DOI: 10.2210/pdb8b87/pdb
PDB entry 8b87 coloured by chain, front view.
PDB entry 8b87 coloured by chain, side view.
PDB entry 8b87 coloured by chain, top view.
Source organisms:
Entry authors: Stewart BZ, Kvansakul M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240791 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein scribble homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 12.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14160 (Residues: 700-815; Coverage: 7%)
Gene names: CRIB1, KIAA0147, LAP4, SCRB1, SCRIB, VARTUL
Sequence domains: PDZ domain
Protein E6 Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.24 KDa
Source organism: Human papillomavirus 16
Expression system: Not provided
UniProt:
  • Canonical: P03126 (Residues: 149-158; Coverage: 6%)
Gene name: E6

Ligands and Environments

3 bound ligands:
Ligand SDY 1 x SDY
Ligand PEG 9 x PEG
Ligand NH4 1 x NH4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 74.62Å b: 31.14Å c: 91.76Å
α: 90° β: 107.56° γ: 90°
R-values:
R R work R free
0.222 0.22 0.256
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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