› 8brc

X-ray diffraction
3.17Å resolution

Crystal structure of the adduct between human serum transferrin and cisplatin

Released:
DOI: 10.2210/pdb8brc/pdb
PDB entry 8brc coloured by chain, front view.
PDB entry 8brc coloured by chain, side view.
PDB entry 8brc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
Troisi R, Galardo F, Ferraro G, Sica F, Merlino A
OpenAccess logo Inorg Chem (2023)
PMID: 36602395

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 679 amino acids
Theoretical weight: 75.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02787 (Residues: 20-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin

Ligands and Environments

5 bound ligands:
Ligand FE 1 x FE
Ligand MLI 1 x MLI
Ligand NAG 1 x NAG
Ligand PT 1 x PT
Ligand NH3 2 x NH3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: C2221
Unit cell:
a: 136.34Å b: 156.4Å c: 107.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.177 0.243

Quick links

Citations

2 citation in other articles

Anticancer Effect of PtIIPHENSS, PtII5MESS, PtII56MESS and Their Platinum(IV)-Dihydroxy Derivatives against Triple-Negative Breast Cancer and Cisplatin-Resistant Colorectal Cancer.
Elias et al. (2024)
1 more

1 mention without citation

Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
Troisi et al. (2023)