› 8dg9

Electron Microscopy
2.24Å resolution

Cryo-EM Structure of RSV prefusion F trimer in complex with three MxR Fabs

Released:
DOI: 10.2210/pdb8dg9/pdb
PDB entry 8dg9 coloured by chain, front view.
PDB entry 8dg9 coloured by chain, side view.
PDB entry 8dg9 coloured by chain, top view.
Source organisms:
Primary publication:
Cross-protective antibodies against common endemic respiratory viruses.
Cabán M, Rodarte JV, Bibby M, Gray MD, Taylor JJ, Pancera M, Boonyaratanakornkit J
OpenAccess logo Nat Commun 14 798 (2023)
PMID: 36781872
Related structures: EMD-27419

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272204 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 569 amino acids
Theoretical weight: 63.53 KDa
Source organism: Respiratory syncytial virus A2
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-516; Coverage: 89%)
Gene name: F
Sequence domains: Fusion glycoprotein F0
mAb MxR Heavy Chain, VH region Chains: D, F, H
Molecule details ›
Chains: D, F, H
Length: 120 amino acids
Theoretical weight: 12.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
mAb MxR Light Chain, VL region Chains: E, G, L

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.24Å
Relevant EMDB volumes: EMD-27419
Expression system: Homo sapiens

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Citations

3 review citations

Does Prior Respiratory Viral Infection Provide Cross-Protection Against Subsequent Respiratory Viral Infections? A Systematic Review and Meta-Analysis.
Gopal et al. (2024)
2 more