8dpu

X-ray diffraction
3.78Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-539585 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Interleukin-6 receptor subunit beta Chains: A, D, G, J, M, P
Molecule details ›
Chains: A, D, G, J, M, P
Length: 303 amino acids
Theoretical weight: 34.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40189 (Residues: 22-324; Coverage: 34%)
Gene name: IL6ST
Sequence domains:
Interleukin-11 Chains: B, E, H, K, N, Q
Molecule details ›
Chains: B, E, H, K, N, Q
Length: 179 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20809 (Residues: 22-199; Coverage: 100%)
Gene name: IL11
Sequence domains: Interleukin 11
Soluble interleukin-11 receptor subunit alpha Chains: C, F, I, L, O, R
Molecule details ›
Chains: C, F, I, L, O, R
Length: 348 amino acids
Theoretical weight: 38.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14626 (Residues: 23-363; Coverage: 85%)
Gene name: IL11RA

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3112
Unit cell:
a: 163.411Å b: 163.411Å c: 506.623Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.276 0.276 0.295
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli BL21(DE3)