8ee5

X-ray diffraction
3.58Å resolution

Function and Biology Details

Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-492215 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope protein E Chain: Z
Molecule details ›
Chain: Z
Length: 405 amino acids
Theoretical weight: 44.21 KDa
Source organism: Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013
Expression system: Insect cell expression vector pTIE1
rhMZ119-D antibody heavy chain Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.3 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
rhMZ119-D antibody light chain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 22.57 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-1
Unit cell:
a: 51.681Å b: 103.672Å c: 196.698Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.249 0.296
Expression systems:
  • Insect cell expression vector pTIE1
  • Homo sapiens