8efb

Electron Microscopy
3.2Å resolution

Oliceridine-bound mu-opioid receptor-Gi complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-543303 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Mu-type opioid receptor Chain: R
Molecule details ›
Chain: R
Length: 367 amino acids
Theoretical weight: 41.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35372 (Residues: 2-368; Coverage: 92%)
Gene names: MOR1, OPRM1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
scFv16 Chain: E

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-28077
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli