› 8eog

Electron Microscopy
3.3Å resolution

Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine

Released:
DOI: 10.2210/pdb8eog/pdb
PDB entry 8eog coloured by chain, front view.
PDB entry 8eog coloured by chain, side view.
PDB entry 8eog coloured by chain, top view.
Source organisms:
Primary publication:
EMC chaperone-CaV structure reveals an ion channel assembly intermediate.
Chen Z, Mondal A, Ali FA, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL
Nature (2023)
PMID: 37196677
Related structures: EMD-28375

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146771 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1050 amino acids
Theoretical weight: 118.94 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P13806 (Residues: 29-1079; Coverage: 97%)
Gene names: CACNA2D1, CACNL2A, CCHL2A
Sequence domains:
Voltage-dependent L-type calcium channel subunit alpha-1C Chain: K
Molecule details ›
Chain: K
Length: 1499 amino acids
Theoretical weight: 170.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13936 (Residues: 112-1658; Coverage: 68%)
  • Best match: Q13936-12 (Residues: 112-1610)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-3 Chain: C
Molecule details ›
Chain: C
Length: 191 amino acids
Theoretical weight: 21.67 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P54286 (Residues: 171-361; Coverage: 40%)
Gene names: CACNB3, CACNLB3
Sequence domains: Guanylate kinase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
7 bound ligands:
Ligand NAG 5 x NAG
Ligand CA 3 x CA
Ligand NA 1 x NA
Ligand LEU 1 x LEU
Ligand CLR 3 x CLR
Ligand WNZ 1 x WNZ
Ligand WO9 1 x WO9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-28375
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Non-ionotropic voltage-gated calcium channel signaling.
Trus et al. (2024)
1 more

3 mentions without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)
2 more