8evb

Electron Microscopy
3.6Å resolution

Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, pre-open state

Released:
Source organism: Homo sapiens
Related structures: EMD-28625

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-172459 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclic nucleotide-gated channel alpha-3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 552 amino acids
Theoretical weight: 63.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16281 (Residues: 151-694; Coverage: 78%)
Gene names: CNCG3, CNGA3
Sequence domains:
Cyclic nucleotide-gated channel beta-3 Chain: D
Molecule details ›
Chain: D
Length: 740 amino acids
Theoretical weight: 84.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NQW8 (Residues: 79-809; Coverage: 90%)
Gene name: CNGB3
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.6Å
Relevant EMDB volumes: EMD-28625
Expression system: Homo sapiens