8ez7

Electron Microscopy
2.6Å resolution

Structure of 1F04 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-275074 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Heavy chain of influenza virus neuraminidase antibody 1F04 Chain: H
Molecule details ›
Chain: H
Length: 126 amino acids
Theoretical weight: 13.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of influenza virus neuraminidase antibody 1F04 Chain: L
Molecule details ›
Chain: L
Length: 110 amino acids
Theoretical weight: 11.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Neuraminidase Chain: A

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.6Å
Relevant EMDB volumes: EMD-28729
Expression systems:
  • Homo sapiens
  • Trichoplusia ni