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Electron Microscopy
3.58Å resolution

Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-226245 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (7 distinct):
PGT145 DU303 Heavy Chain: H
Molecule details ›
Chain: H
Length: 252 amino acids
Theoretical weight: 27.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PGT145 DU303 Light Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: A, B, F
Molecule details ›
Chains: A, B, F
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Transmembrane protein gp41 Chains: C, G, I
Molecule details ›
Chains: C, G, I
Length: 481 amino acids
Theoretical weight: 54.09 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-510; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 3.58Å
Relevant EMDB volumes: EMD-29288
Expression system: Homo sapiens