PDB 8fm8 structure summary ‹ Protein Data Bank in Europe (PDBe)

X-ray diffraction

2.47Å resolution

HIV-1 gp120 complex with CJF-IV-046

Released: 05 Apr 2023

DOI: 10.2210/pdb8fm8/pdb

Source organism: HIV-1 06TG.HT008

Primary publication:
Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.

Fritschi CJ, Anang S, Gong Z, Mohammadi M, Richard J, Bourassa C, Severino KT, Richter H, Yang D, Chen HC, Chiu TJ, Seaman MS, Madani N, Abrams C, Finzi A, Hendrickson WA, Sodroski JG, Smith AB

Proc Natl Acad Sci U S A 120 e2222073120 (2023)

PMID: 36961924

Function and Biology Details

Biochemical function:

not assigned

Biological process:

not assigned

Cellular component:

not assigned

Structure analysis Details

Assembly composition:

monomeric (preferred)

Assembly name:

Envelope glycoprotein gp160 (preferred)

PDBe Complex ID:

PDB-CPX-111575 (preferred)

Entry contents:

1 distinct polypeptide molecule

Macromolecule:

Envelope glycoprotein gp120 Chains: A, B, C, D

Molecule details ›

Chains: A, B, C, D
Length: 358 amino acids
Theoretical weight: 39.76 KDa
Source organism: HIV-1 06TG.HT008
Expression system: Homo sapiens