› 8gjt

X-ray diffraction
3.5Å resolution

Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-116-D1

Released:
DOI: 10.2210/pdb8gjt/pdb
PDB entry 8gjt coloured by chain, front view.
PDB entry 8gjt coloured by chain, side view.
PDB entry 8gjt coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Ding S, Tolbert WD, Zhu H, Lee D, Marchitto L, Higgins T, Zhao X, Nguyen D, Sherburn R, Richard J, Gendron-Lepage G, Medjahed H, Mohammadi M, Abrams C, Pazgier M, Smith AB, Finzi A
OpenAccess logo Viruses 15 (2023)
PMID: 37243271

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 39.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0M3KKW9 (Residues: 1-353; Coverage: 100%)
Gene name: HIV-1 Env
Sequence domains: Envelope glycoprotein GP120

Ligands and Environments

4 bound ligands:
Ligand NAG 10 x NAG
Ligand ZNF 1 x ZNF
Ligand EPE 1 x EPE
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 64.67Å b: 66.01Å c: 87.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.254 0.307
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Prévost et al. (2023)
2 more

2 mentions without citation

Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Ding et al. (2023)
1 more