8hgs

Electron Microscopy
3.81Å resolution

The EGF-bound EGFR ectodomain homodimer

Released:
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the EGFR/HER2 heterodimer.
OpenAccess logo Cell Discov 9 18 (2023)
PMID: 36781849
Related structures: EMD-34746

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-132702 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 736 amino acids
Theoretical weight: 81.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00533 (Residues: 1-683; Coverage: 56%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Epidermal growth factor Chains: C, D
Molecule details ›
Chains: C, D
Length: 57 amino acids
Theoretical weight: 6.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01133 (Residues: 971-1023; Coverage: 5%)
Gene name: EGF
Sequence domains: EGF-like domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.81Å
Relevant EMDB volumes: EMD-34746
Expression systems:
  • Homo sapiens
  • Escherichia coli