8hlp

Electron Microscopy
3.5Å resolution

Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)

Released:
Source organism: Homo sapiens
Related structures: EMD-34880

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-246376 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1C Chain: A
Molecule details ›
Chain: A
Length: 2173 amino acids
Theoretical weight: 243.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13936 (Residues: 1-2221; Coverage: 98%)
  • Best match: Q13936-5 (Residues: 1-2201)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: F
Molecule details ›
Chain: F
Length: 1071 amino acids
Theoretical weight: 121.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1071; Coverage: 97%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-2 Chain: C
Molecule details ›
Chain: C
Length: 632 amino acids
Theoretical weight: 70.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q08289 (Residues: 41-660; Coverage: 94%)
  • Best match: Q08289-4 (Residues: 1-632)
Gene names: CACNB2, CACNLB2, MYSB
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-34880
Expression system: Homo sapiens