› 8j6f

Electron Microscopy
3.3Å resolution

Cryo-EM structure of the Tocilizumab Fab/IL-6R complex

Released:
DOI: 10.2210/pdb8j6f/pdb
PDB entry 8j6f coloured by chain, front view.
PDB entry 8j6f coloured by chain, side view.
PDB entry 8j6f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: She J, Chen L
Related structures: EMD-36003

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242278 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Heavy chain of Tocilizumab Fab Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of Tocilizumab Fab Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Soluble interleukin-6 receptor subunit alpha Chain: I
Molecule details ›
Chain: I
Length: 365 amino acids
Theoretical weight: 40.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08887 (Residues: 1-355; Coverage: 75%)
  • Best match: P08887-2 (Residues: 1-365)
Gene name: IL6R
Sequence domains:
Soluble interleukin-6 receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08887 (Residues: 122-131; Coverage: 2%)
Gene name: IL6R

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-36003
Expression system: Homo sapiens

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