› 8jv7

Electron Microscopy
3.6Å resolution

Cryo-EM structure of the panda P2X7 receptor in complex with PPADS

Released:
DOI: 10.2210/pdb8jv7/pdb
PDB entry 8jv7 coloured by chain, front view.
PDB entry 8jv7 coloured by chain, side view.
PDB entry 8jv7 coloured by chain, top view.
Source organism: Ailuropoda melanoleuca
Primary publication:
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Sheng D, Yue CX, Jin F, Wang Y, Ichikawa M, Yu Y, Guo CR, Hattori M
OpenAccess logo Elife 12 (2024)
PMID: 38578670
Related structures: EMD-36670

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoreceptor 7 intracellular domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 342 amino acids
Theoretical weight: 38.72 KDa
Source organism: Ailuropoda melanoleuca
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: G1M6C4 (Residues: 24-360; Coverage: 56%)
Gene name: P2RX7
Sequence domains: ATP P2X receptor

Ligands and Environments

2 bound ligands:
Ligand NAG 6 x NAG
Ligand UO6 3 x UO6
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-36670
Expression system: Spodoptera frugiperda

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