› 8k10

Electron Microscopy
3.2Å resolution

SID1 transmembrane family member 2

Released:
DOI: 10.2210/pdb8k10/pdb
PDB entry 8k10 coloured by chain, front view.
PDB entry 8k10 coloured by chain, side view.
PDB entry 8k10 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity.
Zheng L, Yang T, Guo H, Qi C, Lu Y, Xiao H, Gao Y, Liu Y, Yang Y, Zhou M, Nguyen HC, Zhu Y, Sun F, Zhang CY, Ji X
OpenAccess logo Cell Res 34 80-83 (2024)
PMID: 37932445
Related structures: EMD-36782

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-218765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
SID1 transmembrane family member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 853 amino acids
Theoretical weight: 97.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBJ9 (Residues: 19-832; Coverage: 100%)
Gene names: CGI-40, PSEC0072, SIDT2, UNQ685/PRO1325
Sequence domains: dsRNA-gated channel SID-1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-36782
Expression system: Spodoptera frugiperda

Quick links

Citations

6 citation in other articles

FSP1 inhibition: pick your pocket.
Bebber et al. (2023)
5 more