› 8p2w

Electron Microscopy
3.76Å resolution

Structure of human SIT1 (focussed map / refinement)

Released:
DOI: 10.2210/pdb8p2w/pdb
PDB entry 8p2w coloured by chain, front view.
PDB entry 8p2w coloured by chain, side view.
PDB entry 8p2w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rödström KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun 15 5503 (2024)
PMID: 38951531
Related structures: EMD-17377

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245890 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 812 amino acids
Theoretical weight: 93.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 1-17, 18-805; Coverage: 100%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains:
Sodium- and chloride-dependent transporter XTRP3 Chain: C
Molecule details ›
Chain: C
Length: 641 amino acids
Theoretical weight: 71.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NP91 (Residues: 1-592; Coverage: 100%)
Gene names: SIT1, SLC6A20, XT3, XTRP3
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.76Å
Relevant EMDB volumes: EMD-17377
Expression system: Homo sapiens

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