› 8pae

X-ray diffraction
1.2Å resolution

Structure of the ectodomain of Atypical Porcine Pestivirus E2 at 1.2A resolution

Released:
DOI: 10.2210/pdb8pae/pdb
PDB entry 8pae coloured by chain, front view.
PDB entry 8pae coloured by chain, side view.
PDB entry 8pae coloured by chain, top view.
Source organism: Atypical porcine pestivirus
Primary publication:
Structural comparison of typical and atypical E2 pestivirus glycoproteins.
Aitkenhead H, Riedel C, Cowieson N, Rümenapf HT, Stuart DI, El Omari K
Structure 32 273-281.e4 (2024)
PMID: 38176409

Function and Biology Details

Reactions catalysed: 
Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Genome polyprotein Chain: AA
Molecule details ›
Chain: AA
Length: 247 amino acids
Theoretical weight: 28.42 KDa
Source organism: Atypical porcine pestivirus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1B1M0D5 (Residues: 700-911; Coverage: 6%)
Sequence domains: Pestivirus envelope glycoprotein E2

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: R3
Unit cell:
a: 101.124Å b: 101.124Å c: 43.124Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.152 0.15 0.18
Expression system: Homo sapiens

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