› 8qcm

Electron Microscopy
2.39Å resolution

ABCG2 in complex with MZ82 and 5D3 Fab

Released:
DOI: 10.2210/pdb8qcm/pdb
PDB entry 8qcm coloured by chain, front view.
PDB entry 8qcm coloured by chain, side view.
PDB entry 8qcm coloured by chain, top view.
Source organisms:
Primary publication:
Modulation of ABCG2 Transporter Activity by Ko143 Derivatives.
Yu Q, Dehghani-Ghahnaviyeh S, Rasouli A, Sadurni A, Kowal J, Bang-Soerensen R, Wen PC, Tinzl-Zechner M, Irobalieva RN, Ni D, Stahlberg H, Altmann KH, Tajkhorshid E, Locher KP
ACS Chem Biol (2024)
PMID: 39445888
Related structures: EMD-18330

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-577687 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Broad substrate specificity ATP-binding cassette transporter ABCG2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 665 amino acids
Theoretical weight: 73.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UNQ0 (Residues: 2-655; Coverage: 100%)
Gene names: ABCG2, ABCP, BCRP, BCRP1, MXR
Sequence domains:
5D3(Fab) light chain variable domain Chains: C, E
Molecule details ›
Chains: C, E
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
5D3(Fab) heavy chain variable domain Chains: D, F
Molecule details ›
Chains: D, F
Length: 221 amino acids
Theoretical weight: 23.84 KDa
Source organism: Mus musculus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand V0U 2 x V0U
Ligand CLR 6 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.39Å
Relevant EMDB volumes: EMD-18330
Expression system: Homo sapiens

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