› 8rm1

Electron Microscopy
3.1Å resolution

Cryo-EM structure of a Foamy Virus fusion glycoprotein in the postfusion conformation

Released:
DOI: 10.2210/pdb8rm1/pdb
PDB entry 8rm1 coloured by chain, front view.
PDB entry 8rm1 coloured by chain, side view.
PDB entry 8rm1 coloured by chain, top view.
Source organism: Simian foamy virus
Primary publication:
Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses.
Fernández I, Bontems F, Brun D, Coquin Y, Goverde CA, Correia BE, Gessain A, Buseyne F, Rey FA, Backovic M
Sci Adv 10 eado7035 (2024)
PMID: 39392890
Related structures: EMD-19348

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280489 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein gp130 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 444 amino acids
Theoretical weight: 52.05 KDa
Source organism: Simian foamy virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: K7YEW5 (Residues: 127-570; Coverage: 45%)
Gene name: env
Sequence domains: Foamy virus envelope protein
Envelope glycoprotein gp130 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 372 amino acids
Theoretical weight: 42.07 KDa
Source organism: Simian foamy virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: K7YEW5 (Residues: 571-907; Coverage: 34%)
Gene name: env
Sequence domains: Foamy virus envelope protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-19348
Expression system: Drosophila melanogaster

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