› 8s1z

X-ray diffraction
3.8Å resolution

Crystal structure of glycosylated human primary amine oxidase AOC3

Released:
DOI: 10.2210/pdb8s1z/pdb
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PDB entry 8s1z coloured by chain, front view.
PDB entry 8s1z coloured by chain, side view.
PDB entry 8s1z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guedez G, Alix M, Salminen TA

Function and Biology Details

Reaction catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (13 distinct):
Amine oxidase [copper-containing] 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 737 amino acids
Theoretical weight: 81.9 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q16853 (Residues: 27-763; Coverage: 97%)
Gene names: AOC3, VAP1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
3 bound ligands:
Ligand CA 8 x CA
Ligand CU 4 x CU
Ligand NAG 5 x NAG
1 modified residue:
Ligand TPQ 4 x TPQ

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: MAX IV BEAMLINE BioMAX
Spacegroup: P43
Unit cell:
a: 127.959Å b: 127.959Å c: 220.361Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.286 0.32
Expression system: Cricetulus griseus

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