› 8t6l

Electron Microscopy
3.3Å resolution

Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B

Released:
DOI: 10.2210/pdb8t6l/pdb
PDB entry 8t6l coloured by chain, front view.
PDB entry 8t6l coloured by chain, side view.
PDB entry 8t6l coloured by chain, top view.
Source organisms:
Primary publication:
Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.
Tonggu L, Wisedchaisri G, Gamal El-Din TM, Lenaeus MJ, Logan MM, Toma T, Du Bois J, Zheng N, Catterall WA
OpenAccess logo Nat Commun 15 2306 (2024)
PMID: 38485923
Related structures: EMD-41071

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147338 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Green fluorescent protein; Sodium channel protein type 5 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1874 amino acids
Theoretical weight: 213.52 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P15389 (Residues: 1-1931; Coverage: 80%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
Gene names: GFP, Scn5a
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
5 bound ligands:
Ligand NAG 3 x NAG
Ligand LBN 10 x LBN
Ligand Y01 11 x Y01
Ligand 9Z9 2 x 9Z9
Ligand YIJ 2 x YIJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-41071
Expression system: Homo sapiens

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