› 8tgv

Electron Microscopy
3.75Å resolution

CryoEM structure of Fab HC84.26-HCV E2 complex

Released:
DOI: 10.2210/pdb8tgv/pdb
PDB entry 8tgv coloured by chain, front view.
PDB entry 8tgv coloured by chain, side view.
PDB entry 8tgv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shahid S, Liqun J, LIu Y, Hasan SS, Mariuzza RA
Related structures: EMD-41245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero undecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275593 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
envelope glycoprotein E2 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 291 amino acids
Theoretical weight: 32.29 KDa
UniProt:
  • Canonical: X4ZFZ7 (Residues: 206-467; Coverage: 46%)
Sequence domains: Hepatitis C virus non-structural protein E2/NS1
HC84.26 Heavy chain Chains: B, E, I, K
Molecule details ›
Chains: B, E, I, K
Length: 255 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
HC84.26 Light chain Chains: C, F, J, L
Molecule details ›
Chains: C, F, J, L
Length: 234 amino acids
Theoretical weight: 25.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.75Å
Relevant EMDB volumes: EMD-41245
Expression system: Homo sapiens

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