› 8tjb

X-ray diffraction
2.45Å resolution

CRYSTAL STRUCTURE OF THE A/Texas/73/2017(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6'-SLNLN

Released:
DOI: 10.2210/pdb8tjb/pdb
PDB entry 8tjb coloured by chain, front view.
PDB entry 8tjb coloured by chain, side view.
PDB entry 8tjb coloured by chain, top view.
Source organism: Influenza A virus (A/Texas/73/2017(H3N2))
Primary publication:
Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site.
Thompson AJ, Wu NC, Canales A, Kikuchi C, Zhu X, de Toro BF, Cañada FJ, Worth C, Wang S, McBride R, Peng W, Nycholat CM, Jiménez-Barbero J, Wilson IA, Paulson JC
Cell Host Microbe (2024)
PMID: 38307019

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239817 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 35.98 KDa
Source organism: Influenza A virus (A/Texas/73/2017(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1W6AW68 (Residues: 27-345; Coverage: 56%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin Chain: B
Molecule details ›
Chain: B
Length: 174 amino acids
Theoretical weight: 20.13 KDa
Source organism: Influenza A virus (A/Texas/73/2017(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1W6AW68 (Residues: 346-519; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: R32
Unit cell:
a: 100.24Å b: 100.24Å c: 391.849Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.242 0.238 0.277
Expression system: Trichoplusia ni

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