› 8tr7

Electron Microscopy
2.53Å resolution

Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977

Released:
DOI: 10.2210/pdb8tr7/pdb
PDB entry 8tr7 coloured by chain, front view.
PDB entry 8tr7 coloured by chain, side view.
PDB entry 8tr7 coloured by chain, top view.
Source organism: Rattus
Primary publication:
P2X7 receptors exhibit at least three modes of allosteric antagonism.
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv 10 eado5084 (2024)
PMID: 39365862
Related structures: EMD-41572

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor 7 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 595 amino acids
Theoretical weight: 68.47 KDa
Source organism: Rattus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64663 (Residues: 1-595; Coverage: 100%)
Gene name: P2rx7
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand KDU 3 x KDU
Ligand GDP 3 x GDP
Ligand ZN 6 x ZN
Ligand NAG 6 x NAG
Ligand PLM 15 x PLM
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.53Å
Relevant EMDB volumes: EMD-41572
Expression system: Homo sapiens

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