› 8tui

X-ray diffraction
2.75Å resolution

Crystal structure of Fab-Lirilumab bound to KIR2DL3

Released:
DOI: 10.2210/pdb8tui/pdb
PDB entry 8tui coloured by chain, front view.
PDB entry 8tui coloured by chain, side view.
PDB entry 8tui coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab.
Lorig-Roach N, Harpell NM, DuBois RM
Sci Rep 14 742 (2024)
PMID: 38185735

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236283 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Lirilumab Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 265 amino acids
Theoretical weight: 27.79 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Lirilumab Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Killer cell immunoglobulin-like receptor 2DL3 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 28.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43628 (Residues: 22-245; Coverage: 70%)
Gene names: CD158B2, KIR2DL3, KIRCL23, NKAT2
Sequence domains: Immunoglobulin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 58.379Å b: 84.27Å c: 62.268Å
α: 90° β: 115.86° γ: 90°
R-values:
R R work R free
0.213 0.211 0.254
Expression systems:
  • Cricetulus griseus
  • Homo sapiens

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