› 8u18

Electron Microscopy
3.6Å resolution

Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo

Released:
DOI: 10.2210/pdb8u18/pdb
PDB entry 8u18 coloured by chain, front view.
PDB entry 8u18 coloured by chain, side view.
PDB entry 8u18 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.
Sarson-Lawrence KTG, Hardy JM, Iaria J, Stockwell D, Behrens K, Saiyed T, Tan C, Jebeli L, Scott NE, Dite TA, Nicola NA, Leis AP, Babon JJ, Kershaw NJ
Nat Commun 15 1135 (2024)
PMID: 38326297
Related structures: EMD-41805

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243761 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombopoietin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 503 amino acids
Theoretical weight: 56.56 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q08351 (Residues: 26-482; Coverage: 76%)
Gene names: Mpl, Tpor
Sequence domains: Erythropoietin receptor, ligand binding
Thrombopoietin Chain: C
Molecule details ›
Chain: C
Length: 181 amino acids
Theoretical weight: 19.61 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P40226 (Residues: 22-184; Coverage: 49%)
Gene name: Thpo
Sequence domains: Erythropoietin/thrombopoietin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 4 x NAG
Ligand MAN 2 x MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-41805
Expression system: Homo sapiens

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