› 8uk3

Electron Microscopy
8Å resolution

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+ (class 6 reconstruction)

Released:
DOI: 10.2210/pdb8uk3/pdb
PDB entry 8uk3 coloured by chain, front view.
PDB entry 8uk3 coloured by chain, side view.
PDB entry 8uk3 coloured by chain, top view.
Source organism: Simian rotavirus A strain RRV
Primary publication:
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2.
de Sautu M, Herrmann T, Scanavachi G, Jenni S, Harrison SC
PLoS Pathog 20 e1011750 (2024)
PMID: 38574119
Related structures: EMD-42344

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 21-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245770 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Outer capsid protein VP4 Chains: 1, 2, 3
Molecule details ›
Chains: 1, 2, 3
Length: 776 amino acids
Theoretical weight: 86.66 KDa
Source organism: Simian rotavirus A strain RRV
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: P12473 (Residues: 1-776; Coverage: 100%)
Sequence domains:
Outer capsid glycoprotein VP7 Chains: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r
Molecule details ›
Chains: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r
Length: 326 amino acids
Theoretical weight: 37.14 KDa
Source organism: Simian rotavirus A strain RRV
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: P12476 (Residues: 1-326; Coverage: 100%)
Sequence domains: Glycoprotein VP7

Ligands and Environments

2 bound ligands:
Ligand NAG 18 x NAG
Ligand CA 54 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8Å
Relevant EMDB volumes: EMD-42344
Expression system: Chlorocebus aethiops

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