8uwc

Electron Microscopy
2.27Å resolution

Site-one protease without SPRING

Released:

Function and Biology Details

Reaction catalysed:
Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-556525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Membrane-bound transcription factor site-1 protease Chain: A
Molecule details ›
Chain: A
Length: 1014 amino acids
Theoretical weight: 113.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14703 (Residues: 24-998; Coverage: 94%)
Gene names: KIAA0091, MBTPS1, S1P, SKI1
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.27Å
Relevant EMDB volumes: EMD-42661
Expression system: Homo sapiens