› 8uwz

X-ray diffraction
3.5Å resolution

The structure of Raamsizumab in complex with VEGF121

Released:
DOI: 10.2210/pdb8uwz/pdb
PDB entry 8uwz coloured by chain, front view.
PDB entry 8uwz coloured by chain, side view.
PDB entry 8uwz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Singer AU, Bruce H, Blazer L, Sicheri F, Adams JJ, Sidhu SS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-538051 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Raamsizumab heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 228 amino acids
Theoretical weight: 24.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Raamsizumab light chain S1C variant Chains: B, D
Molecule details ›
Chains: B, D
Length: 212 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
N-VEGF Chains: E, F
Molecule details ›
Chains: E, F
Length: 121 amino acids
Theoretical weight: 14.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P15692 (Residues: 207-321; Coverage: 29%)
  • Best match: P15692-9 (Residues: 27-147)
Gene names: VEGF, VEGFA
Sequence domains: PDGF/VEGF domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P31
Unit cell:
a: 167.747Å b: 167.747Å c: 42.501Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.243 0.237 0.298
Expression systems:
  • Homo sapiens
  • Not provided

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