› 8v88

Electron Microscopy
2.3Å resolution

Alpha7-nicotinic acetylcholine receptor bound to epibatidine and GAT107

Released:
DOI: 10.2210/pdb8v88/pdb
PDB entry 8v88 coloured by chain, front view.
PDB entry 8v88 coloured by chain, side view.
PDB entry 8v88 coloured by chain, top view.
Source organisms:
Primary publication:
Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation.
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
Cell (2024)
PMID: 38382524
Related structures: EMD-43030

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142079 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Neuronal acetylcholine receptor subunit alpha-7; Soluble cytochrome b562 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 599 amino acids
Theoretical weight: 67.22 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P36544 (Residues: 24-373, 413-502; Coverage: 92%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: CHRNA7, NACHRA7, cybC
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
6 bound ligands:
Ligand CA 5 x CA
Ligand NAG 5 x NAG
Ligand POV 10 x POV
Ligand 9Z9 5 x 9Z9
Ligand EPJ 5 x EPJ
Ligand YLI 5 x YLI
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.3Å
Relevant EMDB volumes: EMD-43030
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

A bupropion modulatory site in the Gloeobacter violaceus ligand-gated ion channel.
Do et al. (2024)
2 more