PDB 8vs6 structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

transforming growth factor beta binding

Biological process:

positive regulation of cell population proliferation

Cellular component:

cell surface

Structure analysis Details

Assembly composition:

hetero trimer (preferred)

Assembly name:

Integrin alphav-beta8 complex and Transforming growth factor beta-3 (preferred)

PDBe Complex ID:

PDB-CPX-272372 (preferred)

Entry contents:

3 distinct polypeptide molecules

Macromolecules (5 distinct):

Transforming growth factor beta-3 proprotein Chain: E

Molecule details ›

Chain: E
Length: 389 amino acids
Theoretical weight: 44.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P10600 (Residues: 24-412; Coverage: 100%)

Gene name: TGFB3
Sequence domains:

Integrin alpha-V Chain: A

Molecule details ›

Chain: A
Length: 962 amino acids
Theoretical weight: 106.38 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:

Canonical: P06756 (Residues: 31-992; Coverage: 95%)

Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:

Integrin beta-8 Chain: B

Molecule details ›

Chain: B
Length: 642 amino acids
Theoretical weight: 71.27 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt: