› 8vse

Electron Microscopy
3.8Å resolution

Cryo-EM structure of human CD45 extracellular region in complex with adenoviral protein E3/49K

Released:
DOI: 10.2210/pdb8vse/pdb
PDB entry 8vse coloured by chain, front view.
PDB entry 8vse coloured by chain, side view.
PDB entry 8vse coloured by chain, top view.
Source organisms:
Primary publication:
Orientation-dependent CD45 inhibition with viral and engineered ligands.
Borowska MT, Liu LD, Caveney NA, Jude KM, Kim WJ, Masubuchi T, Hui E, Majzner RG, Garcia KC
Sci Immunol 9 eadp0707 (2024)
PMID: 39454026
Related structures: EMD-43497

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-530688 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Receptor-type tyrosine-protein phosphatase C Chains: A, B
Molecule details ›
Chains: A, B
Length: 551 amino acids
Theoretical weight: 60.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08575 (Residues: 26-576; Coverage: 43%)
Gene names: CD45, PTPRC
Sequence domains:
E3 protein ( 49Kprotein ) Chain: C
Molecule details ›
Chain: C
Length: 343 amino acids
Theoretical weight: 39.41 KDa
Source organism: Human adenovirus 19a
Expression system: Homo sapiens
UniProt:
  • Canonical: Q67812 (Residues: 20-353; Coverage: 78%)
Gene names: 49K, E3
Sequence domains: Adenovirus E3 region protein CR1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-43497
Expression system: Homo sapiens

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