› 8wot

Electron Microscopy
3.18Å resolution

Cryo-EM structure of human SIDT1 protein with C2 symmetry at low pH

Released:
DOI: 10.2210/pdb8wot/pdb
PDB entry 8wot coloured by chain, front view.
PDB entry 8wot coloured by chain, side view.
PDB entry 8wot coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1.
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
OpenAccess logo Cell Discov 10 21 (2024)
PMID: 38378654
Related structures: EMD-37698

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576406 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
SID1 transmembrane family member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 881 amino acids
Theoretical weight: 99.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NXL6 (Residues: 1-656, 657-827; Coverage: 100%)
  • Best match: Q9NXL6-2 (Residues: 1-832)
Gene name: SIDT1
Sequence domains: dsRNA-gated channel SID-1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand CLR 8 x CLR
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.18Å
Relevant EMDB volumes: EMD-37698
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain.
Navratna et al. (2024)