› 8wox

Electron Microscopy
2.75Å resolution

Cryo-EM structure of SARS-CoV-2 prototype RBD in complex with rabbit ACE2 (local refinement)

Released:
DOI: 10.2210/pdb8wox/pdb
PDB entry 8wox coloured by chain, front view.
PDB entry 8wox coloured by chain, side view.
PDB entry 8wox coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency.
Shi K, Li L, Luo C, Xu Z, Huang B, Ma S, Liu K, Yu G, Gao GF
OpenAccess logo mBio e0298823 (2023)
PMID: 38112468
Related structures: EMD-37701

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236464 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 25.95 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Angiotensin-converting enzyme Chain: A
Molecule details ›
Chain: A
Length: 596 amino acids
Theoretical weight: 69.02 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: G1TEF4 (Residues: 19-614; Coverage: 76%)
Gene name: ACE2
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.75Å
Relevant EMDB volumes: EMD-37701
Expression systems:
  • Homo sapiens
  • Escherichia coli

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