› 8wpg

Electron Microscopy
2.7Å resolution

Human calcium-sensing receptor bound with cinacalcet in detergent

Released:
DOI: 10.2210/pdb8wpg/pdb
PDB entry 8wpg coloured by chain, front view.
PDB entry 8wpg coloured by chain, side view.
PDB entry 8wpg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into asymmetric activation of the calcium-sensing receptor-Gq complex.
Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C
Cell Res (2023)
PMID: 37919470
Related structures: EMD-37716

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Extracellular calcium-sensing receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 903 amino acids
Theoretical weight: 102.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41180 (Residues: 20-892; Coverage: 82%)
Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand NAG 5 x NAG
Ligand TRP 2 x TRP
Ligand CA 4 x CA
Ligand PO4 2 x PO4
Ligand YP4 2 x YP4
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-37716
Expression system: Spodoptera frugiperda

Quick links

Citations

1 citations in other articles

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5.
Li et al. (2024)

1 mention without citation

Molecular regulation of calcium-sensing receptor (CaSR)-mediated signaling.
Tian et al. (2024)